Adaptation of the popular comic book series written by Garth Ennis, the rights to which belong to the publishing house "Vertigo" – one of the divisions of the world famous company"DC Comics". The plot of the series revolves around Jesse Custer-a preacher who lives in a small provincial town of Annville, who by chance becomes a "vessel" for an incredibly powerful supernatural being called Genesis, which is the result of the impossible and absurd by all canons copulation of an angel and a demon. Completely unaware of the magnitude of the enormous power that gave him Genesis, our hero, led by righteous anger, leaves his hometown and goes on a dangerous journey through the vast expanses of the United States, trying to find a God who left heaven to bring the Almighty to account for such a reckless act. In this difficult case, Custer is helped by his ex-girlfriend Tulip O'hara and his best friend Cassidy, who is a vampire alcoholic of Irish origin. During the long journey and trying to find the true answers to inexplicable questions, our heroes will face insurmountable difficulties and incredibly dangerous enemies waiting for them both in the human and spiritual world.