After near School of Superheroes the new school opens, supergirls find themselves in the face of new threat. Now to the Wonderful Female, Supergirls, Bat girls and other it is necessary not only to worry for the estimates, but also for safety of the friends and relatives, and also all residents. Supergirls should fight this time with School of Supervillains!
Amanda Waller brings together the Task Force of Ickx consisting of Dedshot, Harley Quinn, the Captain Bumeranga, the Murderer of Moroz, the Brazen Serpent and the Bronze Tiger again. Their task — to find Steel Maksum and to receive for Amanda the mystical black playing card with the inscription "Free Exit from Hell".
Atom visits the Hall of justice where it meets Batman, the Superman, their pets a German shepherd the Ace and a superdog Crypto and also with the Cyborg. The Wonderful female, Plastikmen and the Fiery Storm join them and they invite Atom to enter League of Justice.
Suddenly the alarm signal arrives and Lois Lane reports that the Joker attacked the Metropolis. It strikes citizens with ridiculous gas and goes to the building of Daily Planet to change it. The batman sends an alarm signal to the Flash and the League of justice goes to the Metropolis.