After parting with the Joker, Harley Quinn decides to completely change her life — she makes a new hairstyle, buys a hyena and destroys the factory "Ace Chemicals", where she swore to be faithful to the Joker, which is why detective Rene Montoya goes on the trail of the criminal. Meanwhile, the most disgusting villain of Gotham Roman Sabonis and his right hand Victor Zas open the hunt for a young thief Cassandra Kane, who stole the necessary diamond for Roman. The girl is also being watched by Sayonis's henchman Black Canary and a Huntress who is interested in the reward for Cassandra's head. However, when the paths of all the heroines intersect, they will have to join forces to jointly act against the criminal boss.
After near School of Superheroes the new school opens, supergirls find themselves in the face of new threat. Now to the Wonderful Female, Supergirls, Bat girls and other it is necessary not only to worry for the estimates, but also for safety of the friends and relatives, and also all residents. Supergirls should fight this time with School of Supervillains!
Amanda Waller brings together the Task Force of Ickx consisting of Dedshot, Harley Quinn, the Captain Bumeranga, the Murderer of Moroz, the Brazen Serpent and the Bronze Tiger again. Their task — to find Steel Maksum and to receive for Amanda the mystical black playing card with the inscription "Free Exit from Hell".
Having got to an action field of the time machine invented by the Gorilla Grodd, Batman is had to medieval Japan. There it turns out that already not bad ояпонившиеся villains of Gotham head certain principalities, and the Joker who reached a certain influence at last waited for arrival of the main enemy. But not all want Bruce Wayne's death — the Catwoman and faithful servant Alfred looked forward to Batman's appearance too.